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Elevated Nuclear Factor Erythroid-2 Levels Promote Epo-Independent Erythroid Maturation and Recapitulate the Hematopoietic Stem Cell and Common Myeloid Progenitor Expansion Observed in Polycythemia Vera Patients

The molecular etiology of polycythemia vera (PV) remains incompletely understood. Patients harbor increased numbers of hematopoietic stem cells and display Epo-independent erythroid maturation. However, the molecular mechanism underlying Epo hypersensitivity and stem cell expansion is unclear. We ha...

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Autors principals: Bogeska, Ruzhica, Pahl, Heike L.
Format: Artigo
Idioma:Inglês
Publicat: AlphaMed Press 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659758/
https://ncbi.nlm.nih.gov/pubmed/23341442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2012-0046
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