Discovery of Small-Molecule Enhancers of Reactive Oxygen Species That are Nontoxic or Cause Genotype-Selective Cell Death

[Image: see text] Elevation of reactive oxygen species (ROS) levels has been observed in many cancer cells relative to nontransformed cells, and recent reports have suggested that small-molecule enhancers of ROS may selectively kill cancer cells in various in vitro and in vivo models. We used a high...

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Autors principals: Adams, Drew J., Boskovic, Zarko V., Theriault, Jimmy R., Wang, Alex J., Stern, Andrew M., Wagner, Bridget K., Shamji, Alykhan F., Schreiber, Stuart L.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2013
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3658551/
https://ncbi.nlm.nih.gov/pubmed/23477340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300653v
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