A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma

[Image: see text] Post-translational modifications of histones alter chromatin structure and play key roles in gene expression and specification of cell states. Small molecules that target chromatin-modifying enzymes selectively are useful as probes and have promise as therapeutics, although very fe...

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Detalhes bibliográficos
Main Authors: Yuan, Yuan, Wang, Qiu, Paulk, Joshiawa, Kubicek, Stefan, Kemp, Melissa M., Adams, Drew J., Shamji, Alykhan F., Wagner, Bridget K., Schreiber, Stuart L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401036/
https://ncbi.nlm.nih.gov/pubmed/22536950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300139y
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