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Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs
Piperlongumine is a naturally occurring small molecule recently identified to be toxic selectively to cancer cells in vitro and in vivo. This compound was found to elevate cellular levels of reactive oxygen species (ROS) selectively in cancer cell lines. The synthesis of 80 piperlongumine analogs ha...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3458345/ https://ncbi.nlm.nih.gov/pubmed/22949699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212802109 |
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