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Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis
Oncogenic transcription factor Myc deregulates the cell cycle and simultaneously reprograms cellular metabolism to meet the biosynthetic and bioenergetic needs of proliferation. Myc also sensitizes cells to mitochondria-dependent apoptosis. Although metabolic reprogramming has been circumstantially...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3657814/ https://ncbi.nlm.nih.gov/pubmed/23589839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208530110 |
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