Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Master transcription factors Oct4, Sox2 and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expression program of pluripotent embryonic stem cells (ESCs). We report here that the ESC master transcription factors form unusual enhancer domains at most genes that control...

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Autori principali: Whyte, Warren A., Orlando, David A., Hnisz, Denes, Abraham, Brian J., Lin, Charles Y., Kagey, Michael H., Rahl, Peter B., Lee, Tong Ihn, Young, Richard A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653129/
https://ncbi.nlm.nih.gov/pubmed/23582322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.03.035
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