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A phase separation model predicts key features of transcriptional control

Super-enhancers are large clusters of enhancers that control transcription of genes with prominent roles in cell-type specific processes in healthy and diseased states. A model that explains the spectrum of observations regarding super-enhancer formation, function and dissolution is lacking. Phase-s...

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Bibliografske podrobnosti
izdano v:Cell
Main Authors: Hnisz, Denes, Shrinivas, Krishna, Young, Richard A., Chakraborty, Arup K., Sharp, Phillip A.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5432200/
https://ncbi.nlm.nih.gov/pubmed/28340338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.02.007
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