Transcription factors activate genes through the phase separation capacity of their activation domains

Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding domains (DBDs) and activation domains (ADs). The DBDs have been well-characterized, but little is known about the mechanisms by which ADs effect gene activation. Here we report that diverse ADs form phase-separa...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell
Main Authors: Boijja, Ann, Klein, Isaac A., Sabari, Benjamin R., Dall’Agnese, Alessandra, Coffey, Eliot L., Zamudio, Alicia V., Li, Charles H., Shrinivas, Krishna, Manteiga, John C., Hannett, Nancy M., Abraham, Brian J., Afeyan, Lena K., Guo, Yang E., Rimel, Jenna K., Fant, Charli B., Schuijers, Jurian, Lee, Tong Ihn, Taatjes, Dylan J., Young, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295254/
https://ncbi.nlm.nih.gov/pubmed/30449618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.10.042
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados