MeCP2 links heterochromatin condensates and neurodevelopmental disease

MeCP2 (methyl CpG binding protein 2) is a key component of constitutive heterochromatin, which plays important roles in chromosome maintenance and transcriptional silencing(1-3). Mutations in MeCP2 cause Rett syndrome (RTT)(3-5), a postnatal progressive neurodevelopmental disorder associated with se...

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Publicado no:Nature
Main Authors: Li, Charles H., Coffey, Eliot L., Dall’Agnese, Alessandra, Hannett, Nancy M., Tang, Xin, Henninger, Jonathan E., Platt, Jesse M., Oksuz, Ozgur, Zamudio, Alicia V., Afeyan, Lena K., Schuijers, Jurian, Liu, X. Shawn, Markoulaki, Styliani, Lungjangwa, Tenzin, LeRoy, Gary, Svoboda, Devon S., Wogram, Emile, Lee, Tong Ihn, Jaenisch, Rudolf, Young, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7735819/
https://ncbi.nlm.nih.gov/pubmed/32698189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2574-4
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