Neutralizing monoclonal antibody against ras oncogene product p21 which impairs guanine nucleotide exchange.

The neutralizing monoclonal antibody Y13-259 severely hampers the nucleotide exchange reaction between p21-bound and exogenous guanine nucleotides but does not interfere with the association of GDP to p21. These results suggest that the nucleotide exchange reaction is critical for p21 function. Inte...

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Autores principales: Hattori, S, Clanton, D J, Satoh, T, Nakamura, S, Kaziro, Y, Kawakita, M, Shih, T Y
Formato: Artigo
Lenguaje:Inglês
Publicado: 1987
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC365309/
https://ncbi.nlm.nih.gov/pubmed/2439901
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