Identification of novel positive allosteric modulators and null modulators at the GABA(A) receptor α+β− interface

BACKGROUND AND PURPOSE: GABA(A) receptors are the major inhibitory neurotransmitter receptors in the mammalian brain and the target of many clinically important drugs interacting with different binding sites. Recently, we demonstrated that CGS 9895 (2-(4-methoxyphenyl)-2H-pyrazolo[4,3-c]quinolin-3(5...

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Главные авторы: Varagic, Zdravko, Wimmer, Laurin, Schnürch, Michael, Mihovilovic, Marko D, Huang, Shengming, Rallapalli, Sundari, Cook, James M, Mirheydari, Pantea, Ecker, Gerhard F, Sieghart, Werner, Ernst, Margot
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Publishing Ltd 2013
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Research Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651663/
https://ncbi.nlm.nih.gov/pubmed/23472852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12151
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