Identification of novel positive allosteric modulators and null modulators at the GABA(A) receptor α+β− interface

BACKGROUND AND PURPOSE: GABA(A) receptors are the major inhibitory neurotransmitter receptors in the mammalian brain and the target of many clinically important drugs interacting with different binding sites. Recently, we demonstrated that CGS 9895 (2-(4-methoxyphenyl)-2H-pyrazolo[4,3-c]quinolin-3(5...

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Detalhes bibliográficos
Main Authors: Varagic, Zdravko, Wimmer, Laurin, Schnürch, Michael, Mihovilovic, Marko D, Huang, Shengming, Rallapalli, Sundari, Cook, James M, Mirheydari, Pantea, Ecker, Gerhard F, Sieghart, Werner, Ernst, Margot
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651663/
https://ncbi.nlm.nih.gov/pubmed/23472852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12151
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