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Subtype selectivity of α+β− site ligands of GABA(A) receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors

BACKGROUND AND PURPOSE: GABA(A) receptors are the major inhibitory neurotransmitter receptors in the mammalian brain and the target of many clinically important drugs interacting with different binding sites. Recently, we demonstrated that CGS 9895 (2-(4-methoxyphenyl)-2H-pyrazolo[4,3-c]quinolin-3(5...

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Détails bibliographiques
Auteurs principaux: Varagic, Zdravko, Ramerstorfer, Joachim, Huang, Shengming, Rallapalli, Sundari, Sarto-Jackson, Isabella, Cook, James, Sieghart, Werner, Ernst, Margot
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651664/
https://ncbi.nlm.nih.gov/pubmed/23472935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12153
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