Subtype selectivity of α+β− site ligands of GABA(A) receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors

BACKGROUND AND PURPOSE: GABA(A) receptors are the major inhibitory neurotransmitter receptors in the mammalian brain and the target of many clinically important drugs interacting with different binding sites. Recently, we demonstrated that CGS 9895 (2-(4-methoxyphenyl)-2H-pyrazolo[4,3-c]quinolin-3(5...

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Bibliographische Detailangaben
Hauptverfasser: Varagic, Zdravko, Ramerstorfer, Joachim, Huang, Shengming, Rallapalli, Sundari, Sarto-Jackson, Isabella, Cook, James, Sieghart, Werner, Ernst, Margot
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2013
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651664/
https://ncbi.nlm.nih.gov/pubmed/23472935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12153
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