Identification of novel positive allosteric modulators and null modulators at the GABA(A) receptor α+β− interface

BACKGROUND AND PURPOSE: GABA(A) receptors are the major inhibitory neurotransmitter receptors in the mammalian brain and the target of many clinically important drugs interacting with different binding sites. Recently, we demonstrated that CGS 9895 (2-(4-methoxyphenyl)-2H-pyrazolo[4,3-c]quinolin-3(5...

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Autores principales: Varagic, Zdravko, Wimmer, Laurin, Schnürch, Michael, Mihovilovic, Marko D, Huang, Shengming, Rallapalli, Sundari, Cook, James M, Mirheydari, Pantea, Ecker, Gerhard F, Sieghart, Werner, Ernst, Margot
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2013
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651663/
https://ncbi.nlm.nih.gov/pubmed/23472852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12151
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