TMPRSS2 Activates the Human Coronavirus 229E for Cathepsin-Independent Host Cell Entry and Is Expressed in Viral Target Cells in the Respiratory Epithelium

Infection with human coronavirus 229E (HCoV-229E) is associated with the common cold and may result in pneumonia in immunocompromised patients. The viral spike (S) protein is incorporated into the viral envelope and mediates infectious entry of HCoV-229E into host cells, a process that depends on th...

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Detalhes bibliográficos
Main Authors: Bertram, Stephanie, Dijkman, Ronald, Habjan, Matthias, Heurich, Adeline, Gierer, Stefanie, Glowacka, Ilona, Welsch, Kathrin, Winkler, Michael, Schneider, Heike, Hofmann-Winkler, Heike, Thiel, Volker, Pöhlmann, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648130/
https://ncbi.nlm.nih.gov/pubmed/23536651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03372-12
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