The Spike Protein of the Emerging Betacoronavirus EMC Uses a Novel Coronavirus Receptor for Entry, Can Be Activated by TMPRSS2, and Is Targeted by Neutralizing Antibodies

The novel human coronavirus EMC (hCoV-EMC), which recently emerged in Saudi Arabia, is highly pathogenic and could pose a significant threat to public health. The elucidation of hCoV-EMC interactions with host cells is critical to our understanding of the pathogenesis of this virus and to the identi...

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Detalhes bibliográficos
Main Authors: Gierer, Stefanie, Bertram, Stephanie, Kaup, Franziska, Wrensch, Florian, Heurich, Adeline, Krämer-Kühl, Annika, Welsch, Kathrin, Winkler, Michael, Meyer, Benjamin, Drosten, Christian, Dittmer, Ulf, von Hahn, Thomas, Simmons, Graham, Hofmann, Heike, Pöhlmann, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648152/
https://ncbi.nlm.nih.gov/pubmed/23468491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00128-13
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