Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression

Ebola (EBOV) and Marburg virus (MARV) cause severe hemorrhagic fever. The host cell proteases cathepsin B and L activate the Zaire ebolavirus glycoprotein (GP) for cellular entry and constitute potential targets for antiviral intervention. However, it is unclear if different EBOV species and MARV eq...

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Publicado en:Virology
Main Authors: Gnirß, Kerstin, Kühl, Annika, Karsten, Christina, Glowacka, Ilona, Bertram, Stephanie, Kaup, Franziska, Hofmann, Heike, Pöhlmann, Stefan
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier Inc. 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7111950/
https://ncbi.nlm.nih.gov/pubmed/22222211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2011.11.031
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