Role of Endosomal Cathepsins in Entry Mediated by the Ebola Virus Glycoprotein

Using chemical inhibitors and small interfering RNA (siRNA), we have confirmed roles for cathepsin B (CatB) and cathepsin L (CatL) in Ebola virus glycoprotein (GP)-mediated infection. Treatment of Ebola virus GP pseudovirions with CatB and CatL converts GP1 from a 130-kDa to a 19-kDa species. Virus...

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Autores principales: Schornberg, Kathryn, Matsuyama, Shutoku, Kabsch, Kirsten, Delos, Sue, Bouton, Amy, White, Judith
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2006
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440424/
https://ncbi.nlm.nih.gov/pubmed/16571833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.8.4174-4178.2006
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