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Protease-Mediated Entry via the Endosome of Human Coronavirus 229E

Human coronavirus 229E, classified as a group I coronavirus, utilizes human aminopeptidase N (APN) as a receptor; however, its entry mechanism has not yet been fully elucidated. We found that HeLa cells infected with 229E via APN formed syncytia when treated with trypsin or other proteases but not i...

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Bibliographic Details
Main Authors: Kawase, Miyuki, Shirato, Kazuya, Matsuyama, Shutoku, Taguchi, Fumihiro
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612384/
https://ncbi.nlm.nih.gov/pubmed/18971274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01933-08
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