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Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry

Human coronaviruses (HCoVs) enter cells via two distinct pathways: the endosomal pathway using cathepsins to activate spike protein and the cell-surface or early endosome pathway using extracellular proteases such as transmembrane protease serine 2 (TMPRSS2). We previously reported that clinical iso...

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Détails bibliographiques
Publié dans:Virology
Auteurs principaux: Shirato, Kazuya, Kawase, Miyuki, Matsuyama, Shutoku
Format: Artigo
Langue:Inglês
Publié: Elsevier Inc. 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7112029/
https://ncbi.nlm.nih.gov/pubmed/29217279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2017.11.012
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