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TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein

The type II transmembrane serine proteases TMPRSS2 and HAT can cleave and activate the spike protein (S) of the severe acute respiratory syndrome coronavirus (SARS-CoV) for membrane fusion. In addition, these proteases cleave the viral receptor, the carboxypeptidase angiotensin-converting enzyme 2 (...

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Detalhes bibliográficos
Main Authors: Heurich, Adeline, Hofmann-Winkler, Heike, Gierer, Stefanie, Liepold, Thomas, Jahn, Olaf, Pöhlmann, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911672/
https://ncbi.nlm.nih.gov/pubmed/24227843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02202-13
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