TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein

The type II transmembrane serine proteases TMPRSS2 and HAT can cleave and activate the spike protein (S) of the severe acute respiratory syndrome coronavirus (SARS-CoV) for membrane fusion. In addition, these proteases cleave the viral receptor, the carboxypeptidase angiotensin-converting enzyme 2 (...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Heurich, Adeline, Hofmann-Winkler, Heike, Gierer, Stefanie, Liepold, Thomas, Jahn, Olaf, Pöhlmann, Stefan
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2014
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911672/
https://ncbi.nlm.nih.gov/pubmed/24227843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02202-13
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares