Different residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2

The spike (S) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) mediates viral entry into target cells. Cleavage and activation of SARS S by a host cell protease is essential for infectious viral entry and the responsible enzymes are potential targets for antiviral intervention. Th...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Reinke, Lennart Michel, Spiegel, Martin, Plegge, Teresa, Hartleib, Anika, Nehlmeier, Inga, Gierer, Stefanie, Hoffmann, Markus, Hofmann-Winkler, Heike, Winkler, Michael, Pöhlmann, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479546/
https://ncbi.nlm.nih.gov/pubmed/28636671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179177
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