TMPRSS2 and TMPRSS4 Facilitate Trypsin-Independent Spread of Influenza Virus in Caco-2 Cells

Proteolysis of influenza virus hemagglutinin by host cell proteases is essential for viral infectivity, but the proteases responsible are not well defined. Recently, we showed that engineered expression of the type II transmembrane serine proteases (TTSPs) TMPRSS2 and TMPRSS4 allows hemagglutinin (H...

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Detalhes bibliográficos
Main Authors: Bertram, Stephanie, Glowacka, Ilona, Blazejewska, Paulina, Soilleux, Elizabeth, Allen, Paul, Danisch, Simon, Steffen, Imke, Choi, So-Young, Park, Youngwoo, Schneider, Heike, Schughart, Klaus, Pöhlmann, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937781/
https://ncbi.nlm.nih.gov/pubmed/20631123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00239-10
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