TMPRSS2 and TMPRSS4 Facilitate Trypsin-Independent Spread of Influenza Virus in Caco-2 Cells

Proteolysis of influenza virus hemagglutinin by host cell proteases is essential for viral infectivity, but the proteases responsible are not well defined. Recently, we showed that engineered expression of the type II transmembrane serine proteases (TTSPs) TMPRSS2 and TMPRSS4 allows hemagglutinin (H...

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Bibliographische Detailangaben
Hauptverfasser: Bertram, Stephanie, Glowacka, Ilona, Blazejewska, Paulina, Soilleux, Elizabeth, Allen, Paul, Danisch, Simon, Steffen, Imke, Choi, So-Young, Park, Youngwoo, Schneider, Heike, Schughart, Klaus, Pöhlmann, Stefan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937781/
https://ncbi.nlm.nih.gov/pubmed/20631123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00239-10
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