Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease

The highly pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) poses a constant threat to human health. The viral spike protein (SARS-S) mediates host cell entry and is a potential target for antiviral intervention. Activation of SARS-S by host cell proteases is essential for SARS-Co...

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Detalhes bibliográficos
Main Authors: Bertram, Stephanie, Glowacka, Ilona, Müller, Marcel A., Lavender, Hayley, Gnirss, Kerstin, Nehlmeier, Inga, Niemeyer, Daniela, He, Yuxian, Simmons, Graham, Drosten, Christian, Soilleux, Elizabeth J., Jahn, Olaf, Steffen, Imke, Pöhlmann, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233180/
https://ncbi.nlm.nih.gov/pubmed/21994442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05300-11
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