Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63

The human coronaviruses (CoVs) severe acute respiratory syndrome (SARS)-CoV and NL63 employ angiotensin-converting enzyme 2 (ACE2) for cell entry. It was shown that recombinant SARS-CoV spike protein (SARS-S) downregulates ACE2 expression and thereby promotes lung injury. Whether NL63-S exerts a sim...

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Detalhes bibliográficos
Main Authors: Glowacka, Ilona, Bertram, Stephanie, Herzog, Petra, Pfefferle, Susanne, Steffen, Imke, Muench, Marcus O., Simmons, Graham, Hofmann, Heike, Kuri, Thomas, Weber, Friedemann, Eichler, Jutta, Drosten, Christian, Pöhlmann, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798380/
https://ncbi.nlm.nih.gov/pubmed/19864379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01248-09
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