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Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

The spike (S) protein of the severe acute respiratory syndrome coronavirus (SARS-CoV) can be proteolytically activated by cathepsins B and L upon viral uptake into target cell endosomes. In contrast, it is largely unknown whether host cell proteases located in the secretory pathway of infected cells...

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Bibliografiset tiedot
Päätekijät: Glowacka, Ilona, Bertram, Stephanie, Müller, Marcel A., Allen, Paul, Soilleux, Elizabeth, Pfefferle, Susanne, Steffen, Imke, Tsegaye, Theodros Solomon, He, Yuxian, Gnirss, Kerstin, Niemeyer, Daniela, Schneider, Heike, Drosten, Christian, Pöhlmann, Stefan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2011
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126222/
https://ncbi.nlm.nih.gov/pubmed/21325420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02232-10
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