Inhibition of Nonsense-Mediated RNA Decay Activates Autophagy

Nonsense-mediated RNA decay (NMD) is an mRNA surveillance mechanism which rapidly degrades select cytoplasmic mRNAs. We and others have shown that NMD is a dynamically regulated process inhibited by amino acid deprivation, hypoxia, and other cellular stresses commonly generated by the tumor microenv...

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Bibliographic Details
Main Authors: Wengrod, Jordan, Martin, Leenus, Wang, Ding, Frischmeyer-Guerrerio, Pamela, Dietz, Harry C., Gardner, Lawrence B.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648072/
https://ncbi.nlm.nih.gov/pubmed/23508110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00174-13
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