Perturbation of thymocyte development in nonsense-mediated decay (NMD)-deficient mice

The random nature of T-cell receptor-β (TCR-β) recombination needed to generate immunological diversity dictates that two-thirds of alleles will be out-of-frame. Transcripts derived from nonproductive rearrangements are cleared by the nonsense-mediated mRNA decay (NMD) pathway, the process by which...

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Main Authors: Frischmeyer-Guerrerio, Pamela A., Montgomery, Robert A., Warren, Daniel S., Cooke, Sara K., Lutz, Johannes, Sonnenday, Christopher J., Guerrerio, Anthony L., Dietz, Harry C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127929/
https://ncbi.nlm.nih.gov/pubmed/21670277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019352108
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