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Perturbation of thymocyte development in nonsense-mediated decay (NMD)-deficient mice
The random nature of T-cell receptor-β (TCR-β) recombination needed to generate immunological diversity dictates that two-thirds of alleles will be out-of-frame. Transcripts derived from nonproductive rearrangements are cleared by the nonsense-mediated mRNA decay (NMD) pathway, the process by which...
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| Päätekijät: | , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2011
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3127929/ https://ncbi.nlm.nih.gov/pubmed/21670277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019352108 |
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