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Regulation of nonsense-mediated mRNA decay: Implications for physiology and disease
Nonsense-mediated mRNA decay (NMD) is an mRNA quality control mechanism that destabilizes aberrant mRNAs harboring premature termination (nonsense) codons (PTCs). Recent studies have shown that NMD also targets mRNAs transcribed from a large subset of wild-type genes. This raises the possibility tha...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3660545/ https://ncbi.nlm.nih.gov/pubmed/23500037 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagrm.2013.03.002 |
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