Inhibition of Nonsense-Mediated RNA Decay by the Tumor Microenvironment Promotes Tumorigenesis

While nonsense-mediated RNA decay (NMD) is an established mechanism to rapidly degrade select transcripts, the physiological regulation and biological significance of NMD are not well characterized. We previously demonstrated that NMD is inhibited in hypoxic cells. Here we show that the phosphorylat...

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Main Authors: Wang, Ding, Zavadil, Jiri, Martin, Leenus, Parisi, Fabio, Friedman, Eugene, Levy, David, Harding, Heather, Ron, David, Gardner, Lawrence B.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2011
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165546/
https://ncbi.nlm.nih.gov/pubmed/21730287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05704-11
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