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Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein.
While the Ras C-terminal CAAX sequence signals modification by a 15-carbon farnesyl isoprenoid, the majority of isoprenylated proteins in mammalian cells are modified instead by a 20-carbon geranylgeranyl moiety. To determine the structural and functional basis for modification of proteins by a spec...
Wedi'i Gadw mewn:
Prif Awduron: | , , , |
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Fformat: | Artigo |
Iaith: | Inglês |
Cyhoeddwyd: |
1992
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Pynciau: | |
Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC364454/ https://ncbi.nlm.nih.gov/pubmed/1375323 |
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