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Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein.

While the Ras C-terminal CAAX sequence signals modification by a 15-carbon farnesyl isoprenoid, the majority of isoprenylated proteins in mammalian cells are modified instead by a 20-carbon geranylgeranyl moiety. To determine the structural and functional basis for modification of proteins by a spec...

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Udgivet i:Mol Cell Biol
Principais autores: Cox, A D, Hisaka, M M, Buss, J E, Der, C J
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364454/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1375323/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.6.2606-2615.1992
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