Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein.
While the Ras C-terminal CAAX sequence signals modification by a 15-carbon farnesyl isoprenoid, the majority of isoprenylated proteins in mammalian cells are modified instead by a 20-carbon geranylgeranyl moiety. To determine the structural and functional basis for modification of proteins by a spec...
Αποθηκεύτηκε σε:
| Εκδόθηκε σε: | Mol Cell Biol |
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| Κύριοι συγγραφείς: | , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Taylor & Francis
1992
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364454/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1375323/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.6.2606-2615.1992 |
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