Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation.

Oncogenic forms of ras proteins are synthesized in the cytosol and must become membrane associated to cause malignant transformation. Palmitic acid and an isoprenoid (farnesol) intermediate in cholesterol biosynthesis are attached to separate cysteine residues near the C termini of H-ras, N-ras, and...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Jackson, J H, Cochrane, C G, Bourne, J R, Solski, P A, Buss, J E, Der, C J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53830/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2183224/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.8.3042
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