Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation.

Oncogenic forms of ras proteins are synthesized in the cytosol and must become membrane associated to cause malignant transformation. Palmitic acid and an isoprenoid (farnesol) intermediate in cholesterol biosynthesis are attached to separate cysteine residues near the C termini of H-ras, N-ras, and...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Jackson, J H, Cochrane, C G, Bourne, J R, Solski, P A, Buss, J E, Der, C J
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1990
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53830/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2183224/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.8.3042
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