Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation.

Oncogenic forms of ras proteins are synthesized in the cytosol and must become membrane associated to cause malignant transformation. Palmitic acid and an isoprenoid (farnesol) intermediate in cholesterol biosynthesis are attached to separate cysteine residues near the C termini of H-ras, N-ras, and...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Jackson, J H, Cochrane, C G, Bourne, J R, Solski, P A, Buss, J E, Der, C J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53830/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2183224/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.8.3042
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