Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity.
We have introduced a variety of amino acid substitutions into carboxyl-terminal CA1A2X sequence (C = cysteine; A = aliphatic; X = any amino acid) of the oncogenic [Val12]Ki-Ras4B protein to identify the amino acids that permit Ras processing (isoprenylation, proteolysis, and carboxyl methylation), m...
שמור ב:
| הוצא לאור ב: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
National Academy of Sciences
1992
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49509/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1631135/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.14.6403 |
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