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The Retinoblastoma Protein Is Required for Ras-Induced Oncogenic Transformation
Most human cancers involve either mutational activation of the Ras oncogenic pathway and/or inactivation of the retinoblastoma tumor suppressor (RB) pathway. Paradoxically, tumors that harbor Ras mutations almost invariably retain expression of a wild-type pRB protein. We explain this phenomenon by...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1367176/ https://ncbi.nlm.nih.gov/pubmed/16449633 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.4.1170-1182.2006 |
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