Structural Features for Functional Selectivity at Serotonin Receptors

Drugs active at G protein-coupled receptors (GPCRs) can differentially modulate either canonical or non-canonical signaling pathways via a phenomenon known as functional selectivity or biased signaling. We report biochemical studies that show that the hallucinogen lysergic acid diethylamide (LSD), i...

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Detalhes bibliográficos
Main Authors: Wacker, Daniel, Wang, Chong, Katritch, Vsevolod, Han, Gye Won, Huang, Xi-Ping, Vardy, Eyal, McCorvy, John D., Jiang, Yi, Chu, Meihua, Siu, Fai Yiu, Liu, Wei, Xu, H. Eric, Cherezov, Vadim, Roth, Bryan L., Stevens, Raymond C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644390/
https://ncbi.nlm.nih.gov/pubmed/23519215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1232808
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