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Structure of the human smoothened receptor 7TM bound to an antitumor agent

The smoothened (SMO) receptor, a key signal transducer in the Hedgehog (Hh) signaling pathway is both responsible for the maintenance of normal embryonic development and implicated in carcinogenesis. The SMO receptor is classified as a class Frizzled (class F) G protein-coupled receptor (GPCR), alth...

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Detalhes bibliográficos
Main Authors: Wang, Chong, Wu, Huixian, Katritch, Vsevolod, Han, Gye Won, Huang, Xi-Ping, Liu, Wei, Siu, Fai Yiu, Roth, Bryan L., Cherezov, Vadim, Stevens, Raymond C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3657389/
https://ncbi.nlm.nih.gov/pubmed/23636324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12167
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