Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody

Monoclonal antibodies provide an attractive alternative to small-molecule therapies for a wide range of diseases. Given the importance of G protein-coupled receptors (GPCRs) as pharmaceutical targets, there has been an immense interest in developing therapeutic monoclonal antibodies that act on GPCR...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ishchenko, Andrii, Wacker, Daniel, Kapoor, Mili, Zhang, Ai, Han, Gye Won, Basu, Shibom, Patel, Nilkanth, Messerschmidt, Marc, Weierstall, Uwe, Liu, Wei, Katritch, Vsevolod, Roth, Bryan L., Stevens, Raymond C., Cherezov, Vadim
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547598/
https://ncbi.nlm.nih.gov/pubmed/28716900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700891114
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