Structural Basis for Molecular Recognition at Serotonin Receptors

Serotonin or 5-hydroxytryptamine (5-HT) regulates a wide spectrum of human physiology through the 5-HT receptor family. We report the crystal structures of the human 5-HT(1B) G protein-coupled receptor bound to the agonist anti-migraine medications ergotamine and dihydroergotamine. The structures re...

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Autores principales: Wang, Chong, Jiang, Yi, Ma, Jinming, Wu, Huixian, Wacker, Daniel, Katritch, Vsevolod, Han, Gye Won, Liu, Wei, Huang, Xi-Ping, Vardy, Eyal, McCorvy, John D., Gao, Xiang, Zhou, Edward X., Melcher, Karsten, Zhang, Chenghai, Bai, Fang, Yang, Huaiyu, Yang, Linlin, Jiang, Hualiang, Roth, Bryan L., Cherezov, Vadim, Stevens, Raymond C., Xu, H. Eric
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644373/
https://ncbi.nlm.nih.gov/pubmed/23519210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1232807
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