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Genomic regions flanking E-box binding sites influence DNA binding specificity of bHLH transcription factors through DNA shape

DNA sequence is a major determinant of the binding specificity of transcription factors (TFs) for their genomic targets. However, eukaryotic cells often express, at the same time, TFs with highly similar DNA binding motifs but distinct in vivo targets. Currently, it is not well understood how TFs wi...

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Autors principals: Gordân, Raluca, Shen, Ning, Dror, Iris, Zhou, Tianyin, Horton, John, Rohs, Remo, Bulyk, Martha L.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640701/
https://ncbi.nlm.nih.gov/pubmed/23562153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.03.014
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