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Genomic regions flanking E-box binding sites influence DNA binding specificity of bHLH transcription factors through DNA shape

DNA sequence is a major determinant of the binding specificity of transcription factors (TFs) for their genomic targets. However, eukaryotic cells often express, at the same time, TFs with highly similar DNA binding motifs but distinct in vivo targets. Currently, it is not well understood how TFs wi...

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Main Authors: Gordân, Raluca, Shen, Ning, Dror, Iris, Zhou, Tianyin, Horton, John, Rohs, Remo, Bulyk, Martha L.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640701/
https://ncbi.nlm.nih.gov/pubmed/23562153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.03.014
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