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Genomic regions flanking E-box binding sites influence DNA binding specificity of bHLH transcription factors through DNA shape

DNA sequence is a major determinant of the binding specificity of transcription factors (TFs) for their genomic targets. However, eukaryotic cells often express, at the same time, TFs with highly similar DNA binding motifs but distinct in vivo targets. Currently, it is not well understood how TFs wi...

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Hlavní autoři: Gordân, Raluca, Shen, Ning, Dror, Iris, Zhou, Tianyin, Horton, John, Rohs, Remo, Bulyk, Martha L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640701/
https://ncbi.nlm.nih.gov/pubmed/23562153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.03.014
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