Rapamycin Inhibits IGF-1-Mediated Up-Regulation of MDM2 and Sensitizes Cancer Cells to Chemotherapy

The Murine Double Minute 2 (MDM2) protein is a key regulator of cell proliferation and apoptosis that acts primarily by inhibiting the p53 tumor suppressor. Similarly, the PI3-Kinase (PI3K)/AKT pathway is critical for growth factor-mediated cell survival. Additionally, it has been reported that AKT...

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Detalhes bibliográficos
Main Authors: Du, Wei, Yi, Yong, Zhang, Haibo, Bergholz, Johann, Wu, Junfeng, Ying, Haoqiang, Zhang, Yujun, Xiao, Zhi-Xiong Jim
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640086/
https://ncbi.nlm.nih.gov/pubmed/23638184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063179
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