ΔNp63α regulates Erk signaling via MKP3 to inhibit cancer metastasis

Reduced expression of the p53 family member p63 has been suggested to play a causative role in cancer metastasis. Here we show that ΔNp63α, the predominant p63 isoform, plays a major role in regulation of cell migration, invasion, and cancer metastasis. We identified MAP Kinase Phosphatase 3 (MKP3)...

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Detalhes bibliográficos
Main Authors: Bergholz, Johann, Zhang, Yujun, Wu, Junfeng, Meng, Le, Walsh, Erica M., Rai, Arun, Sherman, Michael Y., Xiao, Zhi-Xiong Jim
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962654/
https://ncbi.nlm.nih.gov/pubmed/23246965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.564
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