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MDM2/MDMX: Master negative regulators for p53 and RB

MDM2 (mouse double minute 2 homolog) and MDMX (double minute X human homolog, also known as MDM4) are critical negative regulators of tumor protein p53. Our recent work shows that MDMX binds to and promotes degradation of retinoblastoma protein (RB) in an MDM2-dependent manner. In a xenograft tumor...

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書目詳細資料
發表在:Mol Cell Oncol
Main Authors: Hu, Linshan, Zhang, Haibo, Bergholz, Johann, Sun, Shengnan, Xiao, Zhi-Xiong Jim
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905407/
https://ncbi.nlm.nih.gov/pubmed/27308631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1106635
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