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MDM2/MDMX: Master negative regulators for p53 and RB
MDM2 (mouse double minute 2 homolog) and MDMX (double minute X human homolog, also known as MDM4) are critical negative regulators of tumor protein p53. Our recent work shows that MDMX binds to and promotes degradation of retinoblastoma protein (RB) in an MDM2-dependent manner. In a xenograft tumor...
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| Publicado no: | Mol Cell Oncol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4905407/ https://ncbi.nlm.nih.gov/pubmed/27308631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1106635 |
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