Metformin Sensitizes Leukemia Cells to Vincristine via Activation of AMP-activated Protein Kinase

Vincristine is extensively used chemotherapeutic medicine to treat leukemia. However, it remains a critical clinical problem with regard to its toxicity and drug-resistance. AMP-activated protein kinase (AMPK) is an energy sensor that is pivotal in maintaining cell metabolic homeostasis. It is repor...

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Detalhes bibliográficos
Publicado no:J Cancer
Main Authors: Yi, Yong, Gao, Linfeng, Wu, Min, Ao, Juan, Zhang, Chunyan, Wang, Xiaodong, Lin, Min, Bergholz, Johann, Zhang, Yujun, Xiao, Zhi-Xiong Jim
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2017
Assuntos:
Short Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595093/
https://ncbi.nlm.nih.gov/pubmed/28900501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.19873
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